In biochemistry, microbiology and cell culture applications, aspirators are often used for the removal and disposal of liquids. The aspiration pump creates a vacuum in the collection bottle, which pulls in liquids due to the differential pressure. The liquid is collected in the bottle, and can be disposed of when full.

The most common reason for vacuum pump failure in aspiration is the ingestion of liquid into the pump mechanism. Welch aspiration systems integrate features that protect the pump and the application.